Gene Loss

GlossID	Species	Gene Loss Mechanism	Loss Type	Lineage Specific	Evidence	Accession Nr.
GL_8BDLSO	Balaena mysticetus	LOF (frameshift, premature stop, ss)	Full	Yes	Single individual SRA

Type	Excerpt	DOI
Mutation Description	"Regarding the Mysticeti, all identified mutations were conserved across all 4 analyzed species (Fig. 2a and c). Non-disruptive mutations consisting in the deletion and insertion of 1 codon were identified in exon 1 and exon 2, respectively. Also, two conserved premature stop codons were identified in exon 2 and exon 3 (the former was validated by SRA; Supplementary material 2), which were followed by a 1 nucleotide deletion identified in all analyzed species (Fig. 2c, black arrow). Interestingly, this 1 nucleotide deletion is conserved among all cetacean species (Supplementary material 3), suggesting that Ccl27 pseudogenization preceded the divergence of Odonticeti and Mysticeti."	10.1007/s00251-019-01114-z
Timing of Loss	"The conserved mutational pattern observed between Ccl27 Odontoceti and Mysticeti suggests that inactivation occurred in the Cetacea ancestor."	10.1007/s00251-019-01114-z
Phenotypic	"Given the key role of CCL27 in the process of skin inflammation, we Ccl27 hypothesized that the coding sequence might be compromised in Cetacea as suggested by the overall skin inflammatory physiology observed in this lineage (Mouton and Botha 2012; Zabka and Romano 2003)."	10.1007/s00251-019-01114-z