Ψ CCL27 - Sousa chinensis

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_VZ15JI Sousa chinensis LOF (frameshift, premature stop, ss) Full Yes Genomic

Statements

Type Excerpt DOI
Mutation Description "Next, in exon 3, a conserved premature stop codon was identified in all Odontoceti (Fig. 2b, Supplementary material 2). A frameshift mutation by deletion was identified in all species apart from P. catodon, which in turn shows a frameshift mutation before the identified stop codon (Fig. 2b)." 10.1007/s00251-019-01114-z
Timing of Loss "The conserved mutational pattern observed between Ccl27 Odontoceti and Mysticeti suggests that inactivation occurred in the Cetacea ancestor." 10.1007/s00251-019-01114-z
Phenotypic "Given the key role of CCL27 in the process of skin inflammation, we Ccl27 hypothesized that the coding sequence might be compromised in Cetacea as suggested by the overall skin inflammatory physiology observed in this lineage (Mouton and Botha 2012; Zabka and Romano 2003)." 10.1007/s00251-019-01114-z