Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	GAPD2 , GAPDS , HSD-35 , GAPDH-2 , HEL-S-278	Homo sapiens	11	protein-coding		1.2.1.12	609169

Summary

This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0051287	enables NAD binding	IEA

Component (3)

Go ID	Value	Evidence
0005829	is_active_in cytosol	IBA
0005829	located_in cytosol	TAS
0005634	located_in nucleus	HDA

Process (5)

Go ID	Value	Evidence
0030317	involved_in flagellated sperm motility	ISS
0006006	involved_in glucose metabolic process	IEA
0006096	involved_in glycolytic process	IBA
0006096	involved_in glycolytic process	IEA
0045821	involved_in positive regulation of glycolytic process	TAS

Gene Loss events - GAPDHS (21 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_JX46WL	Kogia breviceps	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.cub.2021.05.062
GL_L1JU99	Tursiops aduncus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Delphinidae	10.1016/j.cub.2021.05.062
GL_LMPN4H	Monodon monoceros	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Monodontidae	10.1016/j.cub.2021.05.062
GL_ML7FCM	Neophocaena asiaeorientalis asiaeorientalis	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Phocoenidae	10.1016/j.cub.2021.05.062
GL_OSSPSR	Ziphius cavirostris	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.cub.2021.05.062
GL_PACSPU	Manis javanica	Pholidota	LOF (frameshift, premature stop, ss)	Full	Pholidota	10.1016/j.cub.2021.05.062
GL_RMTKTB	Phocoena phocoena	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Phocoenidae	10.1016/j.cub.2021.05.062
GL_SMJNXB	Peponocephala electra	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Delphinidae	10.1016/j.cub.2021.05.062
GL_T6JMQK	Lagenorhynchus obliquidens	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Delphinidae	10.1016/j.cub.2021.05.062
GL_VL9AWO	Delphinapterus leucas	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Monodontidae	10.1016/j.cub.2021.05.062