Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	GAPD2 , GAPDS , HSD-35 , GAPDH-2 , HEL-S-278	Homo sapiens	11	protein-coding		1.2.1.12	609169

Summary

This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0051287	enables NAD binding	IEA

Component (3)

Go ID	Value	Evidence
0005829	is_active_in cytosol	IBA
0005829	located_in cytosol	TAS
0005634	located_in nucleus	HDA

Process (5)

Go ID	Value	Evidence
0030317	involved_in flagellated sperm motility	ISS
0006006	involved_in glucose metabolic process	IEA
0006096	involved_in glycolytic process	IBA
0006096	involved_in glycolytic process	IEA
0045821	involved_in positive regulation of glycolytic process	TAS

Gene Loss events - GAPDHS (21 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_0SWHWM	Physeter catodon	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Physeteridae	10.1016/j.cub.2021.05.062
GL_2LZXJD	Lipotes vexillifer	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Lipotidae	10.1016/j.cub.2021.05.062
GL_9NELNL	Sousa chinensis	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Delphinidae	10.1016/j.cub.2021.05.062
GL_A3U6QS	Pontoporia blainvillei	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Pontoporiidae	10.1016/j.cub.2021.05.062
GL_AJPMLQ	Mesoplodon bidens	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.cub.2021.05.062
GL_BG5OF8	Heterocephalus glaber	Rodentia	Exon(s) deletion	Full	Heterocephalus	10.1016/j.cub.2021.05.062
GL_CXWFB6	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Delphinidae	10.1016/j.cub.2021.05.062
GL_D7HLAG	Orcinus orca	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Delphinidae	10.1016/j.cub.2021.05.062
GL_EMTF1C	Globicephala melas	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Delphinidae	10.1016/j.cub.2021.05.062
GL_IW6LN1	Inia geoffrensis	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Iniidae	10.1016/j.cub.2021.05.062