Ψ GAPDHS - Manis javanica
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_PACSPU | Manis javanica | LOF (frameshift, premature stop, ss) | Full | Yes | Multiple individual SRA | XM_037021429.1 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "Gapdhs open reading frame (ORF)-disrupting mutations were also identified in other mammals but were only found to be valid in the naked mole rat, known to have a simplified and degenerate sperm,[17] and Pholidota (pangolins; figshare link in Key resources table)." | 10.1016/j.cub.2021.05.062 |
Curator Observations
Gapdhs (glyceraldehyde-3-phosphate dehydrogenase spermatogenic) is a sperm-specific glycolytic enzyme that plays a crucial role in the glycolysis pathway.