Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
TCHHL1 trichohyalin like 1 THHL1 , S100A17 Homo sapiens 3 N/a

Summary

This gene belongs to the S100 fused-type protein (SFTP) gene family, and is located in a cluster of SFTP genes on chromosome 1q21. Several members of this family have been implicated in the development of complex skin disorders. This gene is evolutionarily conserved; its expression appears to be hair-specific and spatially restricted within the distal inner root sheath of the hair follicle. It thus may have an important role in hair morphogenesis. [provided by RefSeq, Aug 2013]

Gene Loss events - TCHHL1 (12 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_8YTAPO Balaenoptera acutorostrata Artiodactyla Gene deletion Full Cetacea 10.1016/j.cub.2021.02.057
GL_B1ARPN Hexaprotodon liberiensis Artiodactyla LOF (frameshift, premature stop, ss) Full Hippopotamidae 10.1016/j.cub.2021.02.057
GL_EUJO09 Dugong dugon Sirenia LOF (frameshift, premature stop, ss) Undetermined No 10.1038/s41598-024-60099-2
GL_F2YYPN Tursiops truncatus Artiodactyla Gene deletion Full Cetacea 10.1016/j.cub.2021.02.057
GL_GXBQVF Manis pentadactyla Pholidota LOF (frameshift, premature stop, ss) Full Manis 10.1007/s00239-023-10118-z
GL_OYTFM0 Phataginus tricuspis Pholidota Gene deletion Full No 10.1007/s00239-023-10118-z
GL_QTFPNK Manis crassicaudata Pholidota LOF (frameshift, premature stop, ss) Full Manis 10.1007/s00239-023-10118-z
GL_RPR8VZ Trichechus manatus Sirenia LOF (frameshift, premature stop, ss) Undetermined No 10.1038/s41598-024-60099-2
GL_TH1NDQ Manis javanica Pholidota LOF (frameshift, premature stop, ss) Full Manis 10.1007/s00239-023-10118-z
GL_UAA3JE Hippopotamus amphibius Artiodactyla LOF (frameshift, premature stop, ss) Full Hippopotamidae 10.1016/j.cub.2021.02.057