Ψ TCHHL1 - Dugong dugon
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_EUJO09 | Dugong dugon | LOF (frameshift, premature stop, ss) | Undetermined | No | Genomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "However, due to premature stop codons the proteins encoded by FLG, FLG2 and TCHHL1 are more than 50% shorter in sirenians than in elephants and humans (Fig. 5A, Supplementary Fig. S7)." | 10.1038/s41598-024-60099-2 |
| Mutation Description | "Both species of sirenians lack the C-terminal motif in the predicted FLG2 and TCHHL1 proteins (Fig. 5B)." | 10.1038/s41598-024-60099-2 |
Curator Observations
Authors indicate that the protein has suffered a large truncation, due to a premature stop codon in the gene, but do not discard a functionality.