Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
ELOVL3 ELOVL fatty acid elongase 3	CIG30 , CIG-30	Homo sapiens	5	protein-coding	ELOVL6 , ELOVL1 , ELOVL7 , ELOVL5 , ELOVL2 , ELOVL4	2.3.1.199	611815

Summary

This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides. [provided by RefSeq, Jul 2013]

GeneOntology

Function (1)

Go ID	Value	Evidence
0009922	enables fatty acid elongase activity	EXP

Component (3)

Go ID	Value	Evidence
0005783	located_in endoplasmic reticulum	IDA
0005789	is_active_in endoplasmic reticulum membrane	IBA
0005789	located_in endoplasmic reticulum membrane	TAS

Process (14)

Go ID	Value	Evidence
0036109	involved_in alpha-linolenic acid metabolic process	TAS
0034625	involved_in fatty acid elongation, monounsaturated fatty acid	IBA
0034625	involved_in fatty acid elongation, monounsaturated fatty acid	IDA
0034626	involved_in fatty acid elongation, polyunsaturated fatty acid	IBA
0034626	involved_in fatty acid elongation, polyunsaturated fatty acid	IDA
0019367	involved_in fatty acid elongation, saturated fatty acid	IBA
0019367	involved_in fatty acid elongation, saturated fatty acid	IDA
0043651	involved_in linoleic acid metabolic process	TAS
0035338	involved_in long-chain fatty-acyl-CoA biosynthetic process	TAS
0120162	involved_in positive regulation of cold-induced thermogenesis	ISS
0030148	involved_in sphingolipid biosynthetic process	IBA
0006636	involved_in unsaturated fatty acid biosynthetic process	IEA
0042761	involved_in very long-chain fatty acid biosynthetic process	IBA
0042761	involved_in very long-chain fatty acid biosynthetic process	IDA

Gene Loss events - ELOVL3 (9 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_6D6MUC	Delphinapterus leucas	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1093/molbev/msz068
GL_9SUUKC	Lipotes vexillifer	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1093/molbev/msz068
GL_9VA0L7	Eschrichtius robustus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1093/molbev/msz068
GL_HIDRFX	Physeter catodon	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1093/molbev/msz068
GL_IWQHLH	Balaenoptera acutorostrata	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1093/molbev/msz068
GL_PU76MS	Orcinus orca	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1093/molbev/msz068
GL_UE9JXI	Balaenoptera bonaerensis	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1093/molbev/msz068
GL_UOFBGB	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1093/molbev/msz068
GL_VH73DP	Balaena mysticetus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1093/molbev/msz068