Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
CNGA2 cyclic nucleotide gated channel subunit alpha 2	CNCA , CNG2 , CNCA1 , OCNC1 , OCNCa , OCNCALPHA	Homo sapiens	7	protein-coding	CNGB1 , CNGB3 , CNGA1 , CNGA4 , CNGA3		300338

Summary

The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]

GeneOntology

Function (1)

Go ID	Value	Evidence
0030552	enables cAMP binding	IEA

Component (6)

Go ID	Value	Evidence
0030660	located_in Golgi-associated vesicle membrane	TAS
0060170	located_in ciliary membrane	ISS
0060170	located_in ciliary membrane	TAS
0017071	part_of intracellular cyclic nucleotide activated cation channel complex	IBA
0098804	located_in non-motile cilium membrane	ISS
0005886	is_active_in plasma membrane	IBA

Process (6)

Go ID	Value	Evidence
0070588	involved_in calcium ion transmembrane transport	IEA
0006816	involved_in calcium ion transport	ISS
0098655	involved_in monoatomic cation transmembrane transport	IBA
0006813	involved_in potassium ion transport	ISS
0007608	involved_in sensory perception of smell	IEA
0006814	involved_in sodium ion transport	ISS

Gene Loss events - CNGA2 (3 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_8TZ2MC	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ympev.2017.01.020
GL_EWYHWN	Physeter catodon	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ympev.2017.01.020
GL_MWNP5J	Orcinus orca	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ympev.2017.01.020