Ψ CNGA2 - Tursiops truncatus

Reference Gene:
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Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_8TZ2MC Tursiops truncatus LOF (frameshift, premature stop, ss) Full No Genomic XM_033849699.1

Statements

Type Excerpt DOI
Functional "(...) functions cyclic nucleotide-gated channel alpha 2 (CNGA2) and cyclic nucleotide-gated channel alpha 4 (CNGA 4) . These loci encode subunits of the olfactory cyclic nucleotide-gated (CNG) channel that is critical for depolarizing OR neurons and initiating action potentials that are sent to the brain (Michalakis et al.,2006; Nache et al., 2016)." 10.1016/j.ympev.2017.01.020
Mutation Description "O. orca and T. truncatus share a premature stop codon in exon 4 and a 1bp frameshift deletion in exon 6." 10.1016/j.ympev.2017.01.020
Phenotypic "Our results favor the echolocation-priority hypothesis for the evolution of OMP in odontocetes, and further suggest that two other olfactory-specific genes, CNGA2 and CNGA4, are inactivatedin some odontocetes." 10.1016/j.ympev.2017.01.020