Gene Loss

Publication Details

Identifier: JB_WJGHRR

Curator: Gonçalo Themudo

DOI: 10.1186/s12862-017-1051-7

PMID: 28851290

Title:

Genetic basis of brain size evolution in cetaceans: insights from adaptive evolution of seven primary microcephaly (MCPH) genes.

Abstract:

Cetacean brain size expansion is an enigmatic event in mammalian evolution, yet its genetic basis remains poorly explored. Here, all exons of the seven primary microcephaly (MCPH) genes that play key roles in size regulation during brain development were investigated in representative cetacean lineages.

Last update:

13-12-2024

Associated Glosses (7 results)

GlossID	Species	Symbol	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_43YT4Y	Mesoplodon densirostris	MCPH1	LOF (frameshift, premature stop, ss)	Full	No	10.1186/s12862-017-1051-7
GL_MAWAF7	Sousa chinensis	MCPH1	LOF (frameshift, premature stop, ss)	Full	No	10.1186/s12862-017-1051-7
GL_N0ZF4A	Kogia sima	MCPH1	LOF (frameshift, premature stop, ss)	Full	No	10.1186/s12862-017-1051-7
GL_OAERMD	Orcinus orca	MCPH1	LOF (frameshift, premature stop, ss)	Full	No	10.1186/s12862-017-1051-7
GL_T3E8MA	Delphinapterus leucas	MCPH1	LOF (frameshift, premature stop, ss)	Full	No	10.1186/s12862-017-1051-7
GL_TVQI6U	Physeter catodon	MCPH1	LOF (frameshift, premature stop, ss)	Full	No	10.1186/s12862-017-1051-7
GL_WP7EXL	Grampus griseus	MCPH1	LOF (frameshift, premature stop, ss)	Full	No	10.1186/s12862-017-1051-7