Ψ MCPH1 - Physeter catodon
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_TVQI6U | Physeter catodon | LOF (frameshift, premature stop, ss) | Full | No | PCR & Sanger Sequencing Multiple | XM_007114976 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "MCPH1 has been pseudogenized in some cetacean lineages because premature stop codons were identified in three species (i.e. beluga Delphinapterus leucas,Risso’s dolphin Grampus griseus and killer whale O. orca) and frameshift insertions/deletions were examined in five cetacean species (including Blainville’s beaked whale Mesoplodon densirostris, dwarf sperm whale Kogia sima, Chinese white dolphin Sousa chinensis, G. griseus,andP. macrocephalus)." | 10.1186/s12862-017-1051-7 |
| Methodology & Validation | "We exclude the possibility that frameshift insertions/deletions and stop codons are the result of sequencing error because we have reamplified these pseudogenized fragment of MCPH1 gene in different samples or using different primers and obtained the same result." | 10.1186/s12862-017-1051-7 |
Curator Observations
frameshift indels