Gene Loss

Publication Details

Identifier: JB_QCI8T9

Curator: Raul Valente

DOI: 10.1016/j.ympev.2017.08.014

PMID: 28851538

Title:

Unusual loss of chymosin in mammalian lineages parallels neo-natal immune transfer strategies.

Abstract:

Gene duplication and loss are powerful drivers of evolutionary change. The role of loss in phenotypic diversification is notably illustrated by the variable enzymatic repertoire involved in vertebrate protein digestion. Among these we find the pepsin family of aspartic proteinases, including chymosin (Cmy). Previous studies demonstrated that Cmy, a neo-natal digestive pepsin, is inactivated in some primates, including humans. This pseudogenization event was hypothesized to result from the acquisition of maternal immune immunoglobulin G (IgG) transfer. By investigating 94 mammalian subgenomes we reveal an unprecedented level of Cmy erosion in placental mammals, with numerous independent events of gene loss taking place in Primates, Dermoptera, Rodentia, Cetacea and Perissodactyla. Our findings strongly suggest that the recurrent inactivation of Cmy correlates with the evolution of the passive transfer of IgG and uncovers a noteworthy case of evolutionary cross-talk between the digestive and the immune system, modulated by gene loss.

Last update:

24-06-2024

Associated Glosses (30 results)

GlossID	Species	Symbol	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_CZQBWS	Pan paniscus	Cym	LOF (frameshift, premature stop, ss)	Full	Hominidae	10.1016/j.ympev.2017.08.014
GL_F6U2VH	Pongo abelii	Cym	LOF (frameshift, premature stop, ss)	Full	Hominidae	10.1016/j.ympev.2017.08.014
GL_F9GI1K	Mesocricetus auratus	Cym	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ympev.2017.08.014
GL_GYEYUQ	Macaca fascicularis	Cym	LOF (frameshift, premature stop, ss)	Full	Cercopithecidae	10.1016/j.ympev.2017.08.014
GL_HRQOAR	Heterocephalus glaber	Cym	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ympev.2017.08.014
GL_IN05RN	Colobus angolensis palliatus	Cym	LOF (frameshift, premature stop, ss)	Full	Cercopithecidae	10.1016/j.ympev.2017.08.014
GL_KHBXKS	Cercocebus atys	Cym	LOF (frameshift, premature stop, ss)	Full	Cercopithecidae	10.1016/j.ympev.2017.08.014
GL_O3HT6S	Pan troglodytes	Cym	LOF (frameshift, premature stop, ss)	Full	Hominidae	10.1016/j.ympev.2017.08.014
GL_PD8NRG	Macaca mulatta	Cym	LOF (frameshift, premature stop, ss)	Full	Cercopithecidae	10.1016/j.ympev.2017.08.014
GL_PUH6DH	Chlorocebus sabaeus	Cym	LOF (frameshift, premature stop, ss)	Full	Cercopithecidae	10.1016/j.ympev.2017.08.014