Gene Loss

Publication Details

Identifier: JB_QCI8T9

Curator: Raul Valente

DOI: 10.1016/j.ympev.2017.08.014

PMID: 28851538

Title:

Unusual loss of chymosin in mammalian lineages parallels neo-natal immune transfer strategies.

Abstract:

Gene duplication and loss are powerful drivers of evolutionary change. The role of loss in phenotypic diversification is notably illustrated by the variable enzymatic repertoire involved in vertebrate protein digestion. Among these we find the pepsin family of aspartic proteinases, including chymosin (Cmy). Previous studies demonstrated that Cmy, a neo-natal digestive pepsin, is inactivated in some primates, including humans. This pseudogenization event was hypothesized to result from the acquisition of maternal immune immunoglobulin G (IgG) transfer. By investigating 94 mammalian subgenomes we reveal an unprecedented level of Cmy erosion in placental mammals, with numerous independent events of gene loss taking place in Primates, Dermoptera, Rodentia, Cetacea and Perissodactyla. Our findings strongly suggest that the recurrent inactivation of Cmy correlates with the evolution of the passive transfer of IgG and uncovers a noteworthy case of evolutionary cross-talk between the digestive and the immune system, modulated by gene loss.

Last update:

24-06-2024

Associated Glosses (30 results)

GlossID	Species	Symbol	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_QFFHC1	Equus caballus	Cym	LOF (frameshift, premature stop, ss)	Full	Perissodactyla	10.1016/j.ympev.2017.08.014
GL_RPQ4NL	Leptonychotes weddellii	Cym	LOF (frameshift, premature stop, ss)	Undetermined	No	10.1016/j.ympev.2017.08.014
GL_TVRSRH	Mandrillus leucophaeus	Cym	LOF (frameshift, premature stop, ss)	Full	Cercopithecidae	10.1016/j.ympev.2017.08.014
GL_TXCBPL	Octodon degus	Cym	Gene deletion	Full	No	10.1016/j.ympev.2017.08.014
GL_UCX6YP	Rhinopithecus bieti	Cym	LOF (frameshift, premature stop, ss)	Full	Cercopithecidae	10.1016/j.ympev.2017.08.014
GL_V8HE8Z	Nomascus leucogenys	Cym	LOF (frameshift, premature stop, ss)	Full	Hylobatidae	10.1016/j.ympev.2017.08.014
GL_VGVTOT	Equus przewalskii	Cym	LOF (frameshift, premature stop, ss)	Full	Perissodactyla	10.1016/j.ympev.2017.08.014
GL_VT0HJF	Macaca nemestrina	Cym	LOF (frameshift, premature stop, ss)	Full	Cercopithecidae	10.1016/j.ympev.2017.08.014
GL_XZKH12	Galeopterus variegatus	Cym	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ympev.2017.08.014
GL_YDC5BO	Chinchilla lanigera	Cym	Gene deletion	Full	No	10.1016/j.ympev.2017.08.014