| Functional |
"In mammals, Mtnr1a and Mtnr1b receptors are involved in the response of the clock machinery to melatonin stimulation (Reppart et al. 1996)." |
10.1007/s00239-021-10025-1 |
| Mutation Description |
"Pilosa species (sloths and anteaters) Mtnr1b gene annotation revealed the presence of several ORF-disrupting mutations, of note a single transversal mutation present in all analyzed species, namely a 2-nucleotide deletion in exon 2 (Fig. 3; Online Resource 4). This mutation was investigated and validated in both Choloepus species (Online Resource 9)." |
10.1007/s00239-021-10025-1 |
| Methodology & Validation |
"Mutational validation was performed through retrieval of raw sequencing reads in (at least) two independent Sequence Read Archive (SRA) projects (when available)." |
10.1007/s00239-021-10025-1 |
| Timing of Loss |
"Interestingly, the mutational profile of melatonin synthesis and signaling genes within Xenarthra, supports the occurrence of independent inactivation events among Xenarthran orders (Cingulata and Pilosa)." |
10.1007/s00239-021-10025-1 |
| Phenotypic |
"Our results strongly suggest a complete landscape of gene loss in Xenarthra, which further reinforce reports suggesting the lack of a pineal gland in several members of this superorder." |
10.1007/s00239-021-10025-1 |