Ψ GSDMB - Manis javanica
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_XKFED7 | Manis javanica | LOF (frameshift, premature stop, ss) | Full | Yes | Multiple individual SRA | XM_037022682.1 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Timing of Loss | "Gsdmb, on the other hand, displayed various mutations conserved across the Manis lineage, including a five-nucleotide deletion in the third exon, which was independently validated by SRAs" | 10.1007/s00239-023-10118-z |
| Phenotypic | "In addition to skin build-up and maintenance, gasdermins, notably Gsdmb and Gsdmd, were shown to affect T-cell differentiation and function, as well as macrophage infiltration, protecting the skin against bacterial infections and contributing to the pathophysiology of skin diseases, such as psoriasis or skin fibrosis (Liu et al. 2021; Yang et al 2022; Ji et al 2023)." | 10.1007/s00239-023-10118-z |