Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| GSDMB gasdermin B | GSDML , PP4052 , GSDMB-1 , PRO2521 | Homo sapiens | 11 | N/a | 611221 |
Summary
This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Alternative splicing and the use of alternative promoters results in multiple transcript variants. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. [provided by RefSeq, Nov 2016]
Gene Loss events - GSDMB (4 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_4UQFQG | Manis pentadactyla | Pholidota | LOF (frameshift, premature stop, ss) | Full | Manis | 10.1007/s00239-023-10118-z |
| GL_90P6FT | Phataginus tricuspis | Pholidota | LOF (frameshift, premature stop, ss) | Full | No | 10.1007/s00239-023-10118-z |
| GL_QCAPVP | Manis crassicaudata | Pholidota | LOF (frameshift, premature stop, ss) | Full | Manis | 10.1007/s00239-023-10118-z |
| GL_XKFED7 | Manis javanica | Pholidota | LOF (frameshift, premature stop, ss) | Full | Manis | 10.1007/s00239-023-10118-z |