Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
GSDMB gasdermin B GSDML , PP4052 , GSDMB-1 , PRO2521 Homo sapiens 11 N/a 611221

Summary

This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Alternative splicing and the use of alternative promoters results in multiple transcript variants. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. [provided by RefSeq, Nov 2016]

Gene Loss events - GSDMB (9 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_4UQFQG Manis pentadactyla Pholidota LOF (frameshift, premature stop, ss) Full Manis 10.1007/s00239-023-10118-z
GL_90P6FT Phataginus tricuspis Pholidota LOF (frameshift, premature stop, ss) Full No 10.1007/s00239-023-10118-z
GL_ANOIR8 Lipotes vexillifer Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1038/s41598-017-17782-4
GL_BYZUCJ Physeter catodon Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1038/s41598-017-17782-4
GL_LFWJLV Orcinus orca Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1038/s41598-017-17782-4
GL_QCAPVP Manis crassicaudata Pholidota LOF (frameshift, premature stop, ss) Full Manis 10.1007/s00239-023-10118-z
GL_RQZP7B Balaenoptera acutorostrata Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1038/s41598-017-17782-4
GL_TWYZB3 Tursiops truncatus Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1038/s41598-017-17782-4
GL_XKFED7 Manis javanica Pholidota LOF (frameshift, premature stop, ss) Full Manis 10.1007/s00239-023-10118-z