Ψ MMP7 - Physeter catodon
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_V0E0UZ | Physeter catodon | LOF (frameshift, premature stop, ss) | Full | Yes | Multiple individual SRA | XM_024115301.3 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "In addition, MMP7—which promotes metastasis when expressed at high levels (Li et al. 2014; Koskensalo et al .2011)—contains a premature stop codon in sperm whales, a putative sperm whale-specific mechanism to reduce cancer incidence." | 10.1093/gbe/evx187 |
| Methodology & Validation | "To further ensure that assembly artifacts are not mistaken for gene losses, we used the Trace Archive Nucleotide BLAST to search inside RNA-Seq sets SRX220358, SRX220357, SRX220356, SRX220355, SRX220354, SRX220353, SRX220352, SRX220351 and SRX220350." | 10.1093/gbe/evx187 |
| Phenotypic | "A loss of several proteases in cetaceans suggests a trend towards a milder inflammatory response relevant to Peto’s paradox: A theory postulated to explain the lower relative incidence of cancer in large mammals (CaulinandMaley2011)." | 10.1093/gbe/evx187 |
Curator Observations
Sperm whale specific gene loss. See supplementary material for more details.