Ψ TCHHL1 - Orcinus orca
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_UF33GW | Orcinus orca | Gene deletion | Full | Yes | Genomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "The entire coding sequence of the gene is deleted in all cetaceans, but the absence of shared breakpoints in the deletion obscures whether it was lost in the common ancestor of all cetaceans or independently in more than one cetacean clade." | 10.1016/j.cub.2021.02.057 |
| Other | ""In particular, the hippo epidermis is much thinner, has shallower rete ridges, and partially preserves epidermal barrier function as hippos spend substantial time on land. These differences may explain why only one EDC gene, TCHHL1 (trichohyalin-like 1), is convergently inactivated in cetaceans and hippos"" | 10.1016/j.cub.2021.02.057 |
Curator Observations
See Supplementary Table 2 for details regarding inactivating mutations.