Ψ MTNR1B - Mirounga leonina

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_TKRIVM Mirounga leonina LOF (frameshift, premature stop, ss) Full No Genomic XM_035008765.1

Statements

Type Excerpt DOI
Functional "In mammals, Mtnr1a and Mtnr1b receptors are involved in the response of the clock machinery to melatonin stimulation (Reppart et al. 1996)." 10.1007/s00239-021-10025-1
Mutation Description "However, and contrary to the pattern found for Mtnr1a, annotation of the collected sequences revealed Mtnr1b gene erosion across multiple species, mostly affecting the Carnivora and Cetaceans but also Pholidota, Sirenia and some Primates (Fig. 4a; Online Resource 4)." 10.1007/s00239-021-10025-1
Methodology & Validation "Mutational validation was performed through retrieval of raw sequencing reads in (at least) two independent Sequence Read Archive (SRA) projects (when available)." 10.1007/s00239-021-10025-1

Curator Observations

Consult Supplementary Data 4.