| Functional |
"Cathepsin E plays a role in macrophage autophagy and in the terminal differentiation of
keratinocytes (88,89). " |
10.1093/nargab/lqz012 |
| Timing of Loss |
"The deletion of exons 1 to 4 is shared between Cetartiodactyla species, showing that this gene was already lost in their common ancestor." See supplementary material ." |
10.1093/nargab/lqz012 |
| Phenotypic |
"A mouse knockout results in itching, encrusted and erythematic skin lesions that resemble the symptoms observed in the common inflamatory skin disease atopic dermatitis (90). CTSE knockout mice exhibit a reduced turnover of interleukins that accumulate systemically, which likely initiates the development of atopic dermatitis (90)." |
10.1093/nargab/lqz012 |
| Other |
"We found that mammals belonging to the cetartiodactyla clade (alpacas, cetaceans, cow, goat and others) have lost the CTSE gene (Supplementary Figure S7), which encodes the aspartic proteinase cathepsin E that is expressed in cells of the immune system and the epidermis." |
10.1093/nargab/lqz012 |