Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| CTSE cathepsin E | CATE | Homo sapiens | 9 | protein-coding | PGA4 , PGA3 , PGA5 , REN , PGC , NAPSA , CTSD | 3.4.23.34 | 116890 |
Summary
This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015]
GeneOntology
Gene Loss events - CTSE (10 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_12JL6I | Camelus bactrianus | Artiodactyla | Exon(s) deletion | Full | Artiodactyla | 10.1093/nargab/lqz012 |
| GL_81B7IJ | Bos taurus | Artiodactyla | Exon(s) deletion | Full | Artiodactyla | 10.1093/nargab/lqz012 |
| GL_CWQK5K | Bison bison | Artiodactyla | Exon(s) deletion | Full | Artiodactyla | 10.1093/nargab/lqz012 |
| GL_FQYW5O | Physeter catodon | Artiodactyla | Exon(s) deletion | Full | Artiodactyla | 10.1093/nargab/lqz012 |
| GL_H5QAU8 | Tursiops truncatus | Artiodactyla | Exon(s) deletion | Full | Artiodactyla | 10.1093/nargab/lqz012 |
| GL_L5HFTR | Pantholops hodgsonii | Artiodactyla | Exon(s) deletion | Full | Artiodactyla | 10.1093/nargab/lqz012 |
| GL_LOZZKL | Orcinus orca | Artiodactyla | Exon(s) deletion | Full | Artiodactyla | 10.1093/nargab/lqz012 |
| GL_NMSDAH | Capra hircus | Artiodactyla | Exon(s) deletion | Full | Artiodactyla | 10.1093/nargab/lqz012 |
| GL_T06CSL | Vicugna pacos | Artiodactyla | Exon(s) deletion | Full | Artiodactyla | 10.1093/nargab/lqz012 |
| GL_UXEZCH | Balaenoptera acutorostrata | Artiodactyla | Exon(s) deletion | Full | Artiodactyla | 10.1093/nargab/lqz012 |