| Functional |
"Loss of POLM has implications for improved tolerance of oxidative DNA lesions. POLM encodes the DNA polymerase Polu, which plays an integral role in DNA damage repair (33)." |
10.1126/sciadv.aaw6671 |
| Timing of Loss |
"In addition to these increased antioxidant levels, we detected the inactivation of POLM in the cetacean stem lineage (Fig. 2A and fig. S6)." |
10.1126/sciadv.aaw6671 |
| Phenotypic |
"Compared with wild-type mice, POLM knockout mice showed significantly reduced mutagenic 8-oxodG translesion synthesis and exhibited a higher endurance when challenged with severe
oxidative stress (38, 39). POLM knockout mice also displayed improved learning abilities and greater liver regenerative capacity at high age (38, 39) but were found to suffer from reduced hematopoiesis and impaired adaptive immunity (40)." |
10.1126/sciadv.aaw6671 |
| Phenotypic |
"Consequently, the benefits of losing POLM may only predominate under frequent exposure to oxidative stress, where its loss reduces the mutagenic potential of ROS, which readily form during repeated ischemia/reperfusion processes in diving mammals." |
10.1126/sciadv.aaw6671 |