| Functional |
"The pathway that degrades uric acid (end product of purinemetabolism) to allantoin consists of three enzymes (36): urate (the salt of uric acid at physiological pH) is oxidized byUOXtoHIU (5-hydroxyisourate);URAH converts HIU to OHCU (2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline); and OHCU is converted by URAD to allantoin, which is excreted in urine." |
10.1093/nargab/lqz012 |
| Mutation Description |
"Our gene loss data showed that elephants have lost URAD." |
10.1093/nargab/lqz012 |
| Phenotypic |
"Both African and Asian elephants (Elephas Maximus) have very low serum uric acid levels of 0.2 and 0.22 mg/dl, respectively (110,111). West Indian manatees (Trichechus manatus) have serum uric acid levels of 0.97 mg/dl for adult and 0.71 mg/dl for calves (112), which is similar to 1.1 mg/dl observed in the related Amazonian manatee (Trichechus inunguis) (113)." |
10.1093/nargab/lqz012 |