Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase	PRHOXNB	Homo sapiens	2	protein-coding		4.1.1.97	615804

Summary

Predicted to enable carboxy-lyase activity. Predicted to be involved in purine-containing compound catabolic process. Predicted to be active in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]

GeneOntology

Function (1)

Go ID	Value	Evidence
0051997	NOT enables 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity	IBA

Component (2)

Go ID	Value	Evidence
0005575	is_active_in cellular_component	ND
0005777	located_in peroxisome	IEA

Process (4)

Go ID	Value	Evidence
0000255	involved_in allantoin metabolic process	IEA
0008150	involved_in biological_process	ND
0006144	involved_in purine nucleobase metabolic process	IEA
0019628	NOT involved_in urate catabolic process	IBA

Gene Loss events - URAD (2 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_NPDZUB	Loxodonta africana	Proboscidea	LOF (frameshift, premature stop, ss)	Full	Elephantidae	10.1093/nargab/lqz012
GL_PJYSAO	Elephas maximus indicus	Proboscidea	LOF (frameshift, premature stop, ss)	Full	Elephantidae	10.1093/nargab/lqz012