Ψ MTNR1B - Manis javanica

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_MX5GTH Manis javanica LOF (frameshift, premature stop, ss) Full Yes Multiple individual SRA

Statements

Type Excerpt DOI
Functional "In mammals, Mtnr1a and Mtnr1b receptors are involved in the response of the clock machinery to melatonin stimulation (Reppart et al. 1996)." 10.1007/s00239-021-10025-1
Mutation Description "Examples of conserved inactivating mutations were found in bears (Ursus sp.) with an in-frame premature stop codon in exon 1, weasels (Mustela sp.) sharing several indels in exon 2 and pangolins with a single nucleotide deletion and an in frame premature stop codon in exon 1 (Online Resources 4 and 13)." 10.1007/s00239-021-10025-1
Methodology & Validation "Mutational validation was performed through retrieval of raw sequencing reads in (at least) two independent Sequence Read Archive (SRA) projects (when available)." 10.1007/s00239-021-10025-1

Curator Observations

Consult Supplementary Data 4 and 13.