| Functional |
"Mammalian sweet taste is primarily mediated by the type 1 taste receptor Tas1r2/Tas1r3, whereas Tas1r1/Tas1r3 act as the principal umami taste receptor." |
10.1073/pnas.1118360109 |
| Mutation Description |
"In exon 2, we detected an A insertion at 70 bp (Fig. 1 A and B and SI Appendix, Fig. S6A). Furthermore, we detected another 10-bp microdeletion between 274 and 275 bp in the second exon (Fig. 1A and SI Appendix, Fig. S6B), a 14-bp insertion between (...). With multiple ORF-disrupting mutations in the coding sequence, the banded linsang Tas1r2 is apparently defective." |
10.1073/pnas.1118360109 |
| Timing of Loss |
"The widespread loss of Tas1r2 in species of the order Carnivora, the variance in their lineages, and the independent pseudogenizing mutations among species in distinct families strongly support the hypothesis that the loss of Tas1r2 occurred independently many times during the evolution of the order Carnivora." |
10.1073/pnas.1118360109 |
| Phenotypic |
"It seems most likely that changes in dietary behavior in the process of becoming obligate carnivores may favor the loss of a functional Tas1r2, arguing for convergent evolution of pseudogenized Tas1r2." |
10.1073/pnas.1118360109 |