Ψ KLK11 - Orcinus orca
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_LSBN1F | Orcinus orca | LOF (frameshift, premature stop, ss) | Full | Yes | Multiple individual SRA | XM_012539232.3 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Functional | "KLK11 is a downstream target of KLK8, since the KLK11 pro-enzyme was shown to be activated by KLK8 in vitro (Eissa, et al. 2011). KLK11 is also expressed in the epidermis (Komatsu, et al. 2005;; Komatsu, et al. 2006) and hippocampus (Mitsui, et al. 2000);; however, its functional role is unknown." | 10.1093/gbe/evx239 |
| Mutation Description | "Based on our observation that KLK11 is not expressed in the dolphin skin (Figure 4), we inspected the coding sequence of this gene. As shown here, we found a number of inactivating mutations in the four cetacean species included in our genome alignment." | 10.1093/gbe/evx239 |
| Timing of Loss | "Several mutations are shared between all four species, suggesting a common loss in the cetacean ancestor. All mutations are also supported by sequencing reads." | 10.1093/gbe/evx239 |
Curator Observations
Data avaliable in supplmentary figure 2 of the reference.