Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| KLK11 kallikrein related peptidase 11 | IEKD , TLSP , PRSS20 | Homo sapiens | 9 | protein-coding | GZMK , GZMA , CFD , AZU1 , GZMM , PRSS57 , CMA1 , GZMH , CTSG , GZMB , KLK3 , KLK2 , KLK1 , KLK6 , KLK15 , KLK13 , KLK14 , KLK8 , KLK7 , KLK4 , KLK5 , KLK9 , KLK10 , PRSS37 , PRSS58 , KLK12 | 604434 |
Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]
GeneOntology
Gene Loss events - KLK11 (4 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_3ZCLG5 | Tursiops truncatus | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Cetacea | 10.1093/gbe/evx239 |
| GL_6NZSBB | Physeter catodon | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Cetacea | 10.1093/gbe/evx239 |
| GL_LATCIF | Balaenoptera acutorostrata | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Cetacea | 10.1093/gbe/evx239 |
| GL_LSBN1F | Orcinus orca | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Cetacea | 10.1093/gbe/evx239 |