Ψ AWAT1 - Orcinus orca

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_LRTU9N Orcinus orca LOF (frameshift, premature stop, ss) Full Yes Genomic

Statements

Type Excerpt DOI
Functional "Produces wax esters in sebaceous glands." 10.1016/j.cub.2021.02.057
Mutation Description "D - Deletion "260-992D (exons 4-7)"" 10.1016/j.cub.2021.02.057
Timing of Loss "48.23 MA" 10.1016/j.cub.2021.02.057
Phenotypic ""cetaceans have inactivating mutations in genes (AWAT1, DGAT2L6, FABP9, ELOVL3, MOGAT3, and MC5R) associated with sebaceous gland function."" 10.1016/j.cub.2021.02.057
Other ""Three of these genes (AWAT1, KRTAP7-1,andABCC11) exhibit inactivating mutations shared between odontocetes and mysticetes, indicating gene loss on the stem cetacean branch."" 10.1016/j.cub.2021.02.057

Curator Observations

See Table 2 for details regarding timing of loss. See Supplementary Table 2 for details regarding inactivating mutations.

Related Glosses

GL_ID Symbol Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_BMJDCK AWAT1 Orcinus orca Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.1093/molbev/msz068