Ψ MASP2 - Physeter catodon
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_K2D4PX | Physeter catodon | Other | Full | Yes | Multiple individual SRA | XM_024125336.2 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Methodology & Validation | "To further ensure that assembly artifacts are not mistaken for gene losses, we used the Trace Archive Nucleotide BLAST to search inside RNA-Seq sets SRX220358, SRX220357, SRX220356, SRX220355, SRX220354, SRX220353, SRX220352, SRX220351 and SRX220350." | 10.1093/gbe/evx187 |
| Phenotypic | "A loss of several proteases in cetaceans suggests a trend towards a milder inflammatory response relevant to Peto’s paradox: A theory postulated to explain the lower relative incidence of cancer in large mammals (CaulinandMaley2011)." | 10.1093/gbe/evx187 |
| Other | "Other proteases, such as TPSAB1 and MASP2 (Figure 1), seem to have been lost in several cetaceans independently." | 10.1093/gbe/evx187 |
Curator Observations
Sperm whale specific gene loss. The authors do not describe the gene loss mechanism but specify that this gene is lost in this species. See supplementary material for more details.