| Functional |
"proper function of the TAS1Rs and TAS2Rs requires their interaction with gustducin, and the GNAT3 (gustducin α-subunit)-KO mice show highly reduced responses to sweet and bitter taste [54]" |
10.1186/s40851-014-0002-z |
| Mutation Description |
"Mammalian GNAT3 gene consists of eight exons, and all exons of GNAT3 except for the 2nd and 3rd exons were found in both KUjira_1.0 and Ttru_1.4 assemblies. Several pseudogenization mutations (frame shift mutations and premature stop codons) were found in both the whale and dolphin GNAT3 sequences, indicating that both whales and dolphins lost the functional GNAT3." |
10.1186/s40851-014-0002-z |
| Methodology & Validation |
"We sequenced 6th exon of the GNAT3 gene and found that all cetaceans have lost the GNAT3, by means of a frame shift" |
10.1186/s40851-014-0002-z |
| Phenotypic |
"These findings suggest that the gustatory capability had been greatly reduced in cetaceans between the Artiodactyla-Cetacea split and the Odontoceti-Mysticeti split." |
10.1186/s40851-014-0002-z |