Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
GNAT3 G protein subunit alpha transducin 3	GDCA , HG1E	Homo sapiens	8	protein-coding	GNAO1 , GNAL , GNAS , GNAI3 , GNAZ , GNAI1 , GNA13 , GNA12 , GNA14 , GNA11 , GNAQ , GNAT2 , GNAT1 , GNAI2	2.3.1.4	139395

Summary

Sweet, bitter, and umami tastes are transmitted from taste receptors by a specific guanine nucleotide binding protein. The protein encoded by this gene is the alpha subunit of this heterotrimeric G protein, which is found not only in the oral epithelium but also in gut tissues. Variations in this gene have been linked to metabolic syndrome. [provided by RefSeq, Dec 2015]

GeneOntology

Function (1)

Go ID	Value	Evidence
0001664	enables G protein-coupled receptor binding	IBA

Component (9)

Go ID	Value	Evidence
0001669	located_in acrosomal vesicle	IEA
0016324	located_in apical plasma membrane	IEA
0005930	located_in axoneme	IEA
0005737	is_active_in cytoplasm	IBA
0005834	part_of heterotrimeric G-protein complex	IBA
0001917	is_active_in photoreceptor inner segment	IBA
0001750	is_active_in photoreceptor outer segment	IBA
0005886	located_in plasma membrane	TAS
0032991	part_of protein-containing complex	IDA

Process (5)

Go ID	Value	Evidence
0007188	involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA
0001580	involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IBA
0035094	involved_in response to nicotine	IEA
0050916	involved_in sensory perception of sweet taste	IBA
0050917	involved_in sensory perception of umami taste	IEA

Gene Loss events - GNAT3 (2 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_DONGDL	Physeter catodon	Artiodactyla	Gene deletion	Full	No	10.1093/icb/icy004
GL_JCSRKF	Balaenoptera acutorostrata	Artiodactyla	Gene deletion	Full	No	10.1093/icb/icy004