Gene Loss

GlossID	Species	Gene Loss Mechanism	Loss Type	Lineage Specific	Evidence	Accession Nr.
GL_HFJ63Q	Tursiops truncatus	Other	Full	No	Genomic

Type	Excerpt	DOI
Methodology & Validation	"For a gene to be classified as lost, we require that a lineage, which descends from an ancestor with an intact gene, exhibits several gene-inactivating mutations that most likely result in a non-functional protein. As gene-inactivating mutations, we consider frameshifting insertions and deletions, inframe stop codon mutations, and splice site-disrupting mutations. In addition, we consider the loss of exons or even entire genes, which could occur due to either large deletions in the genome or the accumulation of numerous mutations that destroy any sequence similarity. For all previously unknown gene losses presented here, we further confirmed the loss by validating the gene-inactivating mutations with unassembled sequencing reads from the respective species."	10.1038/s41467-018-03667-1
Other	"Supplementary Table 3: Previously-known gene losses in non-human primates that were detected by our approach."	10.1038/s41467-018-03667-1

Sup Table 3. Authors do not provide details regarding gene loss mechanism.

GL_ID	Symbol	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_3EA6T6	TAS1R3	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1073/pnas.1118360109
GL_D0OVHF	TAS1R3	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1186/s40851-014-0002-z
GL_F4GNGQ	TAS1R3	Tursiops truncatus	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671