Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
TAS1R3 taste 1 receptor member 3	T1R3	Homo sapiens	6	protein-coding	GPRC6A , TAS1R2 , TAS1R1 , CASR		605865

Summary

The protein encoded by this gene is a G-protein coupled receptor involved in taste responses. The encoded protein can form a heterodimeric receptor with TAS1R1 to elicit the umami taste response, or it can bind with TAS1R2 to form a receptor for the sweet taste response. [provided by RefSeq, Nov 2015]

GeneOntology

Function (1)

Go ID	Value	Evidence
0004930	enables G protein-coupled receptor activity	IBA

Component (6)

Go ID	Value	Evidence
0005794	located_in Golgi apparatus	IDA
0016020	located_in membrane	IC
0005886	is_active_in plasma membrane	IBA
0005886	located_in plasma membrane	IDA
0005886	located_in plasma membrane	TAS
1903767	part_of sweet taste receptor complex	IDA

Process (6)

Go ID	Value	Evidence
0007186	involved_in G protein-coupled receptor signaling pathway	IC
0001582	involved_in detection of chemical stimulus involved in sensory perception of sweet taste	IDA
0050916	involved_in sensory perception of sweet taste	IBA
0050916	involved_in sensory perception of sweet taste	IDA
0050917	involved_in sensory perception of umami taste	IBA
0050917	involved_in sensory perception of umami taste	IDA

Gene Loss events - TAS1R3 (6 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_27IPNS	Orcinus orca	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_3EA6T6	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1073/pnas.1118360109
GL_F4GNGQ	Tursiops truncatus	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_VYW7C1	Zalophus californianus	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1073/pnas.1118360109
GL_WE7BJU	Physeter catodon	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_WIL54H	Balaenoptera acutorostrata	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671