Ψ SLC6A18 - Orcinus orca
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_GXHMTC | Orcinus orca | LOF (frameshift, premature stop, ss) | Full | Yes | Genomic | XM_049708277.1 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Functional | "Our screen revealed the cetacean-specific loss of SLC6A18 (Fig. 3C and fig. S9), which encodes a renal amino acid transporter that participates in reabsorption of arginine and other amino acids in the kidney proximal tubules." | 10.1126/sciadv.aaw6671 |
| Phenotypic | "The loss of the renal amino acid transporter SLC6A18 (solute carrier family 6 member 18) offers an explanation for the low plasma arginine levels in cetaceans and may have contributed to stronger vasoconstriction during the diving response. “" | 10.1126/sciadv.aaw6671 |
| Phenotypic | "This raises the possibility that the evolutionary loss of SLC6A18 in the cetacean stem lineage may have contributed to an increased diving capacity by indirectly enhancing vasoconstriction during the diving response." | 10.1126/sciadv.aaw6671 |
Curator Observations
Authors identified a conserved 2nt deletion in exon 3.