Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
SLC6A18 solute carrier family 6 member 18	Xtrp2	Homo sapiens	12	protein-coding	SLC6A15 , SLC6A20 , SLC6A17 , SLC6A19 , SLC6A16 , SLC6A8 , SLC6A12 , SLC6A13 , SLC6A11 , SLC6A6 , SLC6A4 , SLC6A3 , SLC6A2 , SLC6A1 , SLC6A5 , SLC6A14 , SLC6A9 , SLC6A7		610300

Summary

The SLC6 family of proteins, which includes SLC6A18, act as specific transporters for neurotransmitters, amino acids, and osmolytes like betaine, taurine, and creatine. SLC6 proteins are sodium cotransporters that derive the energy for solute transport from the electrochemical gradient for sodium ions (Hoglund et al., 2005 [PubMed 16125675]).[supplied by OMIM, Apr 2010]

GeneOntology

Function (1)

Go ID	Value	Evidence
0015171	NOT contributes_to amino acid transmembrane transporter activity	IDA

Component (5)

Go ID	Value	Evidence
0016324	located_in apical plasma membrane	ISS
0031526	located_in brush border membrane	IEA
0005886	is_active_in plasma membrane	IBA
0005886	located_in plasma membrane	ISS
0005886	located_in plasma membrane	TAS

Process (8)

Go ID	Value	Evidence
0003333	involved_in amino acid transmembrane transport	IEA
0006865	NOT involved_in amino acid transport	IMP
0006865	involved_in amino acid transport	TAS
0006836	involved_in neurotransmitter transport	IEA
0015804	involved_in neutral amino acid transport	ISS
0071705	involved_in nitrogen compound transport	IBA
1990297	involved_in renal amino acid absorption	ISS
0035725	involved_in sodium ion transmembrane transport	IBA

Gene Loss events - SLC6A18 (4 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_APOI6B	Physeter catodon	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1126/sciadv.aaw6671
GL_BTAUW5	Balaenoptera acutorostrata	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1126/sciadv.aaw6671
GL_GXHMTC	Orcinus orca	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1126/sciadv.aaw6671
GL_UVESKX	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1126/sciadv.aaw6671