Ψ KLKB1 - Physeter catodon
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_GS5SSN | Physeter catodon | Other | Full | No | Multiple individual SRA |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Methodology & Validation | "To further ensure that assembly artifacts are not mistaken for gene losses, we used the Trace Archive Nucleotide BLAST to search inside RNA-Seq sets SRX220358, SRX220357, SRX220356, SRX220355, SRX220354, SRX220353, SRX220352, SRX220351 and SRX220350." | 10.1093/gbe/evx187 |
| Phenotypic | "The aquatic environment, where cetaceans experience hydrostatic pressure and lack of net weight, must prompt compensatory mechanisms in the control of blood pressure and coagulation to avoid hemostatic accidents. Consistent with this, we have confirmed the lack of both F12 and KLKB1, two serine proteases which participate in the kinin-kallikrein system, in all cetaceans." | 10.1093/gbe/evx187 |
Curator Observations
Authors indicate this gene is also lost in all cetaceans, but do not provide further details nor evidence. The authors do not describe the gene loss mechanism but specify that this gene is lost in this species. See supplementary material for more details.
Related Glosses
| GL_ID | Symbol | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|---|
| GL_1UUG3S | KLKB1 | Physeter catodon | Artiodactyla | Gene deletion | Full | Cetacea | 10.1126/sciadv.aaw6671 |