Ψ PGLYRP4 - Elephas maximus indicus
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_FO6RWH | Elephas maximus indicus | LOF (frameshift, premature stop, ss) | Full | No | Genomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "We focused on the genes located between S100A9 and S100A11. PGLYRP3 is free of disruptive mutations, whereas PGLYRP4 contains inactivating mutations in its coding sequence (Supplementary Fig. S4)." | 10.1038/s41598-024-60099-2 |
| Timing of Loss | "Conservation of PGLYRP3 and loss of functional PGLYRP4 was also detected in the elephant, suggesting that the inactivation of PGLYRP4 has occurred in a common ancestor of sirenians and elephants." | 10.1038/s41598-024-60099-2 |
Curator Observations
Authors suggest that the loss of PGLYRP4 occurred in the common ancestor of sirenians and elephants, yet sequence alignment evidence only demonstrates loss in sirenians. No sequences details are provided for Elephas.