Ψ MTNR1B - Pongo abelii
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_FM2MOA | Pongo abelii | LOF (frameshift, premature stop, ss) | Polymorphic | No | Multiple individual SRA | XM_002822349.3 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Functional | "In mammals, Mtnr1a and Mtnr1b receptors are involved in the response of the clock machinery to melatonin stimulation (Reppart et al. 1996)." | 10.1007/s00239-021-10025-1 |
| Mutation Description | "However, and contrary to the pattern found for Mtnr1a, annotation of the collected sequences revealed Mtnr1b gene erosion across multiple species, mostly affecting the Carnivora and Cetaceans but also Pholidota, Sirenia and some Primates (Fig. 4a; Online Resource 4)." | 10.1007/s00239-021-10025-1 |
| Methodology & Validation | "Mutational validation was performed through retrieval of raw sequencing reads in (at least) two independent Sequence Read Archive (SRA) projects (when available)." | 10.1007/s00239-021-10025-1 |
Curator Observations
This mutation is not shared between all the individuals from this species, meaning that, some individuals present the stop codon and some present the coding aminoacid. Consult Supplementary Data 4 and 13.