Ψ SLC4A9 - Trichechus manatus
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_DYKVXB | Trichechus manatus | LOF (frameshift, premature stop, ss) | Full | No | Genomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Functional | "SLC4A9 encodes an electroneutral ion exchange protein (51), which is expressed in the submandibular salivary gland. SLC4A9 is restricted to the basolateral membrane of acinar cells, where it participates in saliva secretion (Fig. 4B) (52)." | 10.1126/sciadv.aaw6671 |
| Mutation Description | "We found that SLC4A9, a gene participating in saliva secretion, was lost in the cetacean stem lineage (Fig. 4A and fig. S10). Moreover, we found a convergent inactivation of this gene in the manatee, representing the only other fully aquatic mammalian lineage (fig. S10)." | 10.1126/sciadv.aaw6671 |
Curator Observations
See reference supplementary material.