Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
SLC4A9 solute carrier family 4 member 9	AE4	Homo sapiens	23	protein-coding	SLC4A11 , SLC4A4 , SLC4A5 , SLC4A7 , SLC4A10 , SLC4A8 , SLC4A1 , SLC4A3 , SLC4A2		610207

Summary

The protein encoded by this gene is a membrane protein involved in anion exchange. Expression of this gene is mostly limited to the kidney. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneOntology

Function (1)

Go ID	Value	Evidence
0140900	enables chloride:bicarbonate antiporter activity	ISS

Component (4)

Go ID	Value	Evidence
0045177	located_in apical part of cell	IEA
0016323	is_active_in basolateral plasma membrane	IBA
0005886	is_active_in plasma membrane	IBA
0005886	located_in plasma membrane	TAS

Process (7)

Go ID	Value	Evidence
0015701	involved_in bicarbonate transport	IBA
0015701	involved_in bicarbonate transport	TAS
1902476	involved_in chloride transmembrane transport	IEA
0051453	involved_in regulation of intracellular pH	IBA
0046541	involved_in saliva secretion	IEA
0035725	involved_in sodium ion transmembrane transport	ISS
0055085	involved_in transmembrane transport	IBA

Gene Loss events - SLC4A9 (5 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_5HLSFH	Physeter catodon	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1126/sciadv.aaw6671
GL_AWMF1G	Balaenoptera acutorostrata	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1126/sciadv.aaw6671
GL_DYKVXB	Trichechus manatus	Sirenia	LOF (frameshift, premature stop, ss)	Full	No	10.1126/sciadv.aaw6671
GL_MCDYPB	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1126/sciadv.aaw6671
GL_SHMMSN	Orcinus orca	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1126/sciadv.aaw6671