Ψ ASIC4 - Phocoena sinus
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_D0V5HT | Phocoena sinus | LOF (frameshift, premature stop, ss) | Full | Yes | Genomic | XM_032637979.1 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Functional | "Acid-sensing ion channel (ASIC) 4 promotes the degradation of ASIC1 or inhibits its expression." | 10.3390/ani12243571 |
| Mutation Description | "(...) ASCI4 was identified to be pseudogenized in all toothed whales except the sperm whale due to premature stop codons detected in the first exon of the sequences (Figures 1 and S1)." | 10.3390/ani12243571 |
| Phenotypic | "ASIC1 is the most abundant proton-gated ion channel gene in mammals. It is involved in the transmission of pain signals, and its degradation or reduced expression can lead to insensitivity to pain [64]. Therefore, the relaxed selection (and pseudogenization) of ASIC4 in toothed whales may have deprived it of its inhibitory effect on ASIC1, thereby making toothed whales more sensitive to pain." | 10.3390/ani12243571 |
Curator Observations
Shared premature stop codon in exon1 indicates a ancestral loss in Odontoceti with the exception of sperm whales.