Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
ASIC4 acid sensing ion channel subunit family member 4 ACCN4 , BNAC4 Homo sapiens 14 protein-coding SCNN1G , SCNN1D , SCNN1B , SCNN1A , ASIC5 , ASIC2 , ASIC3 , ASIC1 606715

Summary

This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012]

GeneOntology

Gene Loss events - ASIC4 (9 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_B4HUGK Lipotes vexillifer Artiodactyla LOF (frameshift, premature stop, ss) Full 10.3390/ani12243571
GL_D0V5HT Phocoena sinus Artiodactyla LOF (frameshift, premature stop, ss) Full 10.3390/ani12243571
GL_FQKKNP Globicephala melas Artiodactyla LOF (frameshift, premature stop, ss) Full 10.3390/ani12243571
GL_HSQIJN Lagenorhynchus obliquidens Artiodactyla LOF (frameshift, premature stop, ss) Full 10.3390/ani12243571
GL_IQGY71 Monodon monoceros Artiodactyla LOF (frameshift, premature stop, ss) Full 10.3390/ani12243571
GL_K7M9QQ Neophocaena asiaeorientalis asiaeorientalis Artiodactyla LOF (frameshift, premature stop, ss) Full 10.3390/ani12243571
GL_MBMESK Delphinapterus leucas Artiodactyla LOF (frameshift, premature stop, ss) Full 10.3390/ani12243571
GL_PAVPK8 Tursiops truncatus Artiodactyla LOF (frameshift, premature stop, ss) Full 10.3390/ani12243571
GL_SW1CQ9 Orcinus orca Artiodactyla LOF (frameshift, premature stop, ss) Full 10.3390/ani12243571