Ψ CASP12 - Physeter catodon
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_BNJWYA | Physeter catodon | Other | Full | No | Multiple individual SRA |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Methodology & Validation | "To further ensure that assembly artifacts are not mistaken for gene losses, we used the Trace Archive Nucleotide BLAST to search inside RNA-Seq sets SRX220358, SRX220357, SRX220356, SRX220355, SRX220354, SRX220353, SRX220352, SRX220351 and SRX220350." | 10.1093/gbe/evx187 |
| Phenotypic | "A loss of several proteases in cetaceans suggests a trend towards a milder inflammatory response relevant to Peto’s paradox: A theory postulated to explain the lower relative incidence of cancer in large mammals (CaulinandMaley2011)." | 10.1093/gbe/evx187 |
| Other | "We found that several proteases related to the immune system, including MMP12 and CASP12, were lost early during the evolution of cetaceans." | 10.1093/gbe/evx187 |
Curator Observations
Authors indicate this gene is also lost in other cetaceans, but do not provide further details nor evidence. The authors do not describe the gene loss mechanism but specify that this gene is lost in this species. See supplementary material for more details.