| Functional |
"Comparative genomics showed that NLRP10, PYDC1, and CASP14, which are transcriptionally upregulated during human keratinocyte differentiation, lack functional orthologs in cetaceans (Fig. 3B; Suppl. Fig. S12)» (Lachner et al., 2017, p. 6)." |
10.1038/s41598-017-17782-4 |
| Methodology & Validation |
"The genome sequences (…) were investigated for the presence and sequence integrity of genes related to pyroptosis and IL-1 signaling." |
10.1038/s41598-017-17782-4 |
| Timing of Loss |
"The species distribution of these genes, including presence in basal placental mammals, suggests that these genes were present in an ancestor of cetaceans. However, only CASP14 was lost specifically in cetaceans whereas NLRP10 and PYDC1, which are not conserved in several mammalian lineages (our unpublished data), were likely lost in a common (terrestrial) ancestor of cattle and cetaceans (Fig. 3B)." |
10.1038/s41598-017-17782-4 |
| Other |
"Screening gene expression levels in human tissues suggested that NLRP10, PYDC1, and CASP14 are predominantly expressed in epidermal keratinocytes (Suppl. Fig. S10)." |
10.1038/s41598-017-17782-4 |