Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| PYDC1 pyrin domain containing 1 | ASC2 , POP1 , PYC1 , cPOP1 | Homo sapiens | 2 | protein-coding | 615700 |
Summary
Enables protein serine/threonine kinase binding activity and protein serine/threonine kinase inhibitor activity. Involved in innate immune response; negative regulation of signal transduction; and positive regulation of interleukin-1 beta production. Located in cytosol and nucleus. Part of IkappaB kinase complex. [provided by Alliance of Genome Resources, Jan 2025]
Gene Loss events - PYDC1 (7 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_ATJKZI | Lipotes vexillifer | Artiodactyla | Other | Full | No | 10.1038/s41598-017-17782-4 |
| GL_CDNQFD | Bos taurus | Artiodactyla | Other | Full | No | 10.1038/s41598-017-17782-4 |
| GL_E0WVT5 | Elephantulus edwardii | Macroscelidea | Other | Full | No | 10.1038/s41598-017-17782-4 |
| GL_JTUYBM | Orcinus orca | Artiodactyla | Other | Full | No | 10.1038/s41598-017-17782-4 |
| GL_LA6QJY | Physeter catodon | Artiodactyla | Other | Full | No | 10.1038/s41598-017-17782-4 |
| GL_VC19BO | Tursiops truncatus | Artiodactyla | Other | Full | No | 10.1038/s41598-017-17782-4 |
| GL_XSACLL | Balaenoptera acutorostrata | Artiodactyla | Other | Full | No | 10.1038/s41598-017-17782-4 |