Ψ AWAT2 - Manis crassicaudata
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_9UVZOR | Manis crassicaudata | LOF (frameshift, premature stop, ss) | Full | Yes | Genomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Timing of Loss | "Similarly to Awat1, Awat2 displays a mutational pattern concurrent with the inactivation of the gene in the stem of the pangolin clade, exhibiting a conserved loss of a canonical splice site in exon 6 and lack of terminal stop codon in all examined species." | 10.1007/s00239-023-10118-z |
| Phenotypic | "Ancestral (i.e., Awat1, Awat2, Aadacl3) and independent (i.e., Dgat2l6) pseudogenization events in genes associated with epidermal lipids and sebum production strongly suggest a progressive impairment of the sebum-producing molecular machinery in pangolin lineages." | 10.1007/s00239-023-10118-z |