| Functional |
"Notably, the set of IL1F genes lost in cetaceans (Fig. 1F) included all human IL1F orthologs (IL36B, IL37, and IL38) that were upregulated more than a 100-fold during keratinocyte differentiation (Fig. 1E)." |
10.1038/s41598-017-17782-4 |
| Mutation Description |
"Premature stop leads to loss of 7 aa at C-terminus; uncertain effect on function." |
10.1038/s41598-017-17782-4 |
| Methodology & Validation |
"The genome sequences (…) were investigated for the presence and sequence integrity of genes related to pyroptosis and IL-1 signaling." |
10.1038/s41598-017-17782-4 |
| Timing of Loss |
"The mutations in other IL1F genes appear to be compatible with both a single, early gene loss event (as indicated in the phylogenetic tree on the left of Fig. 1F) and inactivations of these genes after the split of cetacean lineages. This pattern of presence and absence of genes indicates that IL36A, IL36B, IL37, IL37-like, and IL38 were inactivated during or after the land-to-water transition, most likely in close association with the loss of the epidermal cornification program in cetaceans." |
10.1038/s41598-017-17782-4 |