Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| IL36B interleukin 36 beta | FIL1 , FIL1H , IL1F8 , IL1H2 , IL-1F8 , IL-1H2 , IL1-ETA , FIL1-(ETA) , FILI-(ETA) | Homo sapiens | 8 | protein-coding | IL1F10 , IL1RN , IL36A , IL37 , IL36G , IL36RN , IL18 , IL1A , IL1B | 605508 |
Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Loss events - IL36B (5 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_8Q9TEP | Balaenoptera acutorostrata | Artiodactyla | LOF (frameshift, premature stop, ss) | Undetermined | No | 10.1038/s41598-017-17782-4 |
| GL_DZ8SH3 | Orcinus orca | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Cetacea | 10.1038/s41598-017-17782-4 |
| GL_KCC962 | Physeter catodon | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1038/s41598-017-17782-4 |
| GL_KGQHEP | Lipotes vexillifer | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1038/s41598-017-17782-4 |
| GL_WFBNWN | Tursiops truncatus | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1038/s41598-017-17782-4 |